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A Simple Plant with Unprecedented Benefits

Over 70% of our immune system is found in the gut. Our proprietary Acemannan Aloe vera extract provides a unique formulation of the most powerful immune-balancing fractions of Acemannan to provide the body with targeted immune support where it counts — in the gut.

  • A proprietary concentration of the most immune-activating Acemannan fractions from the inner leaf gel of the Aloe vera plant
  • “Smart” immune-modulating impact may help the body lower overactive immune systems or activate sluggish ones
Studies have shown that Acemannans with a molecular weight of 400 KDa or less are powerful immune cell activators, while those with larger than 400 KDa support only marginal immunomodulatory activity. Acemannans with a molecular weight of less than 50 KDa can be absorbed immediately through the intestinal walls and transported into the blood stream. Once absorbed, they are transported directly to other cells, tissues and organs throughout the body. Mannans are essential for all cellular functions, including those involved in repair, regeneration and defense.
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* Immune Support (Evolv Immūn), C, P, and A were ranked based on their respective Total Acemannan. Numerous other samples were tested, however they did not qualify for inclusion in the graph because they lacked the full range of immunomodulatory Acemannan. For each sample listed, the Total Acemannan was calculated using the “o-acetyl method,” then checked against the SEC (Size Exclusion Chromatohgraphy) for accuracy The SEC data was also used to determine the <50 kDA and <400 kDa fractions. Both tests were performed by different, independent laboratories using blind samples. 
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Throughout the 1990s and early 2000s, the processing of stabilized Aloe vera changed very little. Then in 2005, the discovery was made that only specifically-sized fractions of Acemannan (Aloe vera’s bioactive molecule) were small enough to be absorbed directly into the blood stream, and other slightly larger fractions actually facilitated the plant’s amazing immunomodulatory effect. The largest fractions of Acemannan become prebiotic nourishment for friendly bacteria in the gut.

With this new information, Dr. Santiago Rodriguez, one of the world’s leading experts on Aloe Acemannan processing, developed Evolv Immūn—a proprietary Acemannan composition. Evolv Immūn is a revolutionary new Aloe vera extract with a proprietary concentration of these immune activating and bioavailable Acemannan fractions, making it a powerful, non-toxic addition your integrative health strategy to support the body’s normal functions of defense, repair, and regeneration.